Probios Oral Boluses contain a source of live, naturally occurring microorganisms. Dosage for 1/4 oz bolus: Dairy and beef calves under 400 lbs - 1 bolus; Calves over 400 lbs - 2 boluses; Cows - 4 boluses at freshening; Sheep & goats - 1 bolus. Dosage for 1/2 oz bolus: Dairy and beef calves under 400 lbs - 1/2 bolus; Calves over 400 lbs - 1 bolus; Cows - 2 boluses at freshening; Sheep and goats - 1/2 bolus.